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Author: Stephen Jones
The classical pathway for activation of NF-kB, a key transcriptional
regulator of the immune system, is controlled by the IKK complex. Activated IKK
phosphorylates IkB which is ubiquitinated and rapidly degraded, allowing NF-kB
to translocate from the cytoplasm to the nucleus where it activates gene
transcription. However, the mechanisms regarding IKK activation have been
elusive. Now CARMA1, Bcl-10, and MALT1 are helping to fill in the blanks of IKK
activation. These proteins are downstream of the T cell receptor (TCR) and
upstream of the IKK complex (Fig. 1). Antigen-TCR signaling in the adaptive
immune system leads to PKC-q activation and formation of an
oligomerization-ubiquitination (Ub)-phosphorylation (P) pathway leading to
activated IKK. Oligomerization-Ub-P pathways have also been found to mediate
NF-kB activation through TLR (Toll-like receptor) signaling; suggesting these
emerging IKK activation pathways may play key roles in regulating both adaptive
and innate immunity.
IMGENEX offers a complete line of antibodies, inhibitors, ELISA assays, and
RNAi kits to complement your NF-kB & TLR signaling studies. Visit our
IMGENEX to learn how we can help you accelerate your research.
IMGENEX India Pvt Ltd. the only biotech company in Orissa and one of its
kinds in Eastern India. IMGENEX India started in Oct as an outsourcing branch of
IMGENEX Corporation,San Diego, USA. Find
out more information about NF-kB.
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